The Ecological Structure Activity Relationships (ECOSAR) Class Program is a computerized predictive system that estimates aquatic toxicity. The program estimates a chemical's acute (short-term) toxicity and chronic (long-term or delayed) toxicity to aquatic organisms such as fish, aquatic invertebrates, and aquatic plants by using computerized Structure Activity Relationships (SARs).
ECOSAR uses structure-activity relationships (SARs) to predict the aquatic toxicity of untested chemicals based on their structural similarity to chemicals for which aquatic studies are available. Application of structure activity relationships is a technique routinely used by the U.S. EPA Office of Pollution Prevention and Toxics under the New Chemicals Program to estimate the toxicity of chemicals being reviewed in response to Pre-Manufacture Notices mandated under Section 5 of the Toxic Substances Control Act (TSCA). The toxicity data used to build the SARs are collected from publicly available experimental studies and confidential submissions provided to the U.S. EPA New Chemicals Program. The SARs in ECOSAR express correlations between a compound's physicochemical properties and its toxicity within specific chemical classes.
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